Symposium Overview / Vision Statement
This symposium is designed to advance the use of biologic scaffolds for regenerative medicine and all general surgery applications. The objectives (stated below) will be accomplished by a series of “state-of-the-art” presentations describing the potential benefits and risks associated with the use of such materials, factors that affect performance of such materials, and the clinical applications that may benefit most from their use. When appropriate, biologic scaffolds materials will be contrasted with synthetic biomaterials. Topics in the various sessions include the most basic science of scaffold design, in vivo remodeling at the molecular, cell, and tissue levels, and the host immune response in both preclinical and clinical studies. It is not the intent of this symposium to discuss only the beneficial aspects of biologic scaffold materials, but importantly, to identify the problem areas associated with these materials, develop strategies for solving these problems, and hopefully initiate collaborations among basic scientists and clinicians in attendance at the meeting. Our feedback from previous symposia (this is a bi-annual event) consistently identifies the equal mix of clinicians and basic scientists as the most rewarding aspect of the meeting.
Although many topic areas will be considered, the 2018 symposium will definitely include the following objectives:
1. To identify and discuss recent findings regarding the mechanisms by which biologic scaffolds facilitate constructive and functional tissue remodeling. The audience should develop a thorough understanding of the mechanisms that are accepted as fact, those that are controversial, and novel mechanisms yet to be investigated.
2. To obtain a thorough understanding of matrix ultrastructure and composition. The audience will be exposed to leaders in the field of matrix biology (Robert Mecham) and composition (Kirk Hansen) and will be exposed to the most current techniques to explore matrix structure and composition.
3. To learn the status of clinical studies in which ECM bioscaffolds are currently being used, including cardiovascular (Karen Christman, Laura Niklason, Christopher Breuer) and esophageal (Stephen Badylak).
4. To understand the innate and adaptive immune response to biologic scaffold materials. Experts in the field of immunology and regenerative medicine (Albert Mantovani, Jennifer Elisseeff, Stephen Badylak) will give presentations and be available for discussions on this important topic.